Attenuation of a phosphorylation-dependent activator by an HDAC–PP1 complex

  title={Attenuation of a phosphorylation-dependent activator by an HDAC–PP1 complex},
  author={Gianluca Canettieri and Ianessa G Morantte and Ernesto Guzm{\'a}n and Hiroshi Asahara and Stephan Herzig and Scott D. Anderson and John R. Yates and Marc R. Montminy},
  journal={Nature Structural Biology},
The second messenger cAMP stimulates transcription with burst-attenuation kinetics that mirror the PKA-dependent phosphorylation and subsequent protein phosphatase 1 (PP1)–mediated dephosphorylation of the cAMP responsive element binding protein (CREB) at Ser133. Phosphorylation of Ser133 promotes recruitment of the co-activator histone acetylase (HAT) paralogs CBP and P300, which in turn stimulate acetylation of promoter-bound histones during the burst phase. Remarkably, histone deacetylase… CONTINUE READING
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