Attenuation of SARS coronavirus by a short hairpin RNA expression plasmid targeting RNA-dependent RNA polymerase.

Abstract

Severe acute respiratory syndrome (SARS) is a highly contagious and sometimes a lethal disease, which spread over five continents in 2002-2003. Laboratory analysis showed that the etiologic agent for SARS is a new type of coronavirus. Currently, there is no specific treatment for this disease. RNA interference (RNAi) is a recently discovered antiviral… (More)

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@article{Lu2004AttenuationOS, title={Attenuation of SARS coronavirus by a short hairpin RNA expression plasmid targeting RNA-dependent RNA polymerase.}, author={Aili Lu and Huanqing Zhang and Xiaoyan Zhang and Hongxia Wang and Qikuan Hu and Li Shen and Brian S. Schaffhausen and Weimin Hou and Linsong Li}, journal={Virology}, year={2004}, volume={324 1}, pages={84-9} }