Attenuation of Murray Valley encephalitis virus by site-directed mutagenesis of the hinge and putative receptor-binding regions of the envelope protein.

@article{Hurrelbrink2001AttenuationOM,
  title={Attenuation of Murray Valley encephalitis virus by site-directed mutagenesis of the hinge and putative receptor-binding regions of the envelope protein.},
  author={Robert J. Hurrelbrink and Peter Charles McMinn},
  journal={Journal of virology},
  year={2001},
  volume={75 16},
  pages={7692-702}
}
Molecular determinants of virulence in flaviviruses cluster in two regions on the three-dimensional structure of the envelope (E) protein; the base of domain II, believed to serve as a hinge during pH-dependent conformational change in the endosome, and the lateral face of domain III, which contains an integrin-binding motif Arg-Gly-Asp (RGD) in mosquito-borne flaviviruses and is believed to form the receptor-binding site of the protein. In an effort to better understand the nature of… CONTINUE READING

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Studies on the molecular pathogenesis of Murray Valley encephalitis infection of mice

  • P. C. McMinn
  • 1994
Highly Influential
9 Excerpts

Mutagenesis of the RGD motif in the yellow fever virus 17D envelope protein

  • R. G. van der Most, J. Corver, J. H. Strauss
  • Virology
  • 1999
Highly Influential
4 Excerpts

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