• Corpus ID: 9493029

Attenuation of Monosodium Glutamate-Induced Hepatic and Testicular Toxicity in Albino Rats by Annona Muricata Linn . ( Annonaceae ) Leaf Extract 1

@inproceedings{AbdElla2016AttenuationOM,
  title={Attenuation of Monosodium Glutamate-Induced Hepatic and Testicular Toxicity in Albino Rats by Annona Muricata Linn . ( Annonaceae ) Leaf Extract 1},
  author={Eman M. Abd-Ella and Abdulrashid Mohammed and A. Mohammed},
  year={2016}
}

• E. Abd-Ella, A. Mohammed, A. Mohammed
• Published 2016
• Biology

Introduction and aim of the work: The protective effects of ANNONA MURICATA LINN leaf extract (Graviola) against orally administered Monosodium glutamate (MSG) for 4 weeks induced hepatic and testicular toxicity on male albino rats were examined. Methods: The rats were divided into 4 groups • Group 1: Served as negative control: The rats were daily orally administrated with ml of distilled water for 4 weeks. • Group 2: Served as control Graviola group: The rats were orally administrated with Graviola leaf extract dissolved in distilled water at a dose level of 100 mg/kg body weight for 4 weeks. • Group 3: Served as control mono-sodium glutamate group (MSG): The rats were orally administrated with monosodium glutamate dissolved in distilled water at a dose level of 4mg/kg b.wt, for 4 weeks. • Group 4: served as treatment group: The rats were orally administrated with monosodium glutamate dissolved in distilled water at a dose level of 4mg/kg b.wt, for 4 weeks, then followed by treatment with Graviola leaf extract dissolved in distilled water at a dose level of 100 mg/kg body weight for another 4 successive weeks. Liver and testes were examined for alterations in BCL-2 and Caspase-3 protein expression and histopathology. Results: MSG up-regulated BCL-2 and Caspase-3 expression in LIVER AND TESTES where Caspase-3 expression was significantly increased (p<0.05) and BCL-2 expression was significantly (P<0.05) decreased but ANNONA MURICATA LINN leaf extract (Graviola) administration as a therapeutic treatment almost normalized the histological and immunohisto chemical alterations. Conclusion: present findings confirmed the protective and therapeutic effects of ANNONA MURICATA LINN leaf extract (Graviola) on MSG induced alteration in liver and testes in male albino rats.