Attenuation of Laboratory-Induced Stress in Humans After Acute Administration of Melissa officinalis (Lemon Balm)

@article{Kennedy2004AttenuationOL,
  title={Attenuation of Laboratory-Induced Stress in Humans After Acute Administration of Melissa officinalis (Lemon Balm)},
  author={David O. Kennedy and Wendy Little and Andrew Scholey},
  journal={Psychosomatic Medicine},
  year={2004},
  volume={66},
  pages={607-613}
}
OBJECTIVE Melissa officinalis (lemon balm) is contemporaneously used as a mild sedative and/or calming agent. [] Key MethodMETHODS In this double-blind, placebo-controlled, randomized, balanced crossover experiment, 18 healthy volunteers received two separate single doses of a standardized M. officinalis extract (300 mg, 600 mg) and a placebo, on separate days separated by a 7-day washout period.
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192 Citations
Highly Influential Citations
3
Background Citations
55
Methods Citations
4
Results Citations
6

192 Citations

Citation Type

Citation Type

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TLDR
Both active lemon balm treatments were generally associated with improvements in mood and/or cognitive performance, though there were some behavioral “costs” at other doses and these effects depended to some degree on the delivery matrix.
Modulation of Mood and Cognitive Performance Following Acute Administration of Single Doses of Melissa Officinalis (Lemon Balm) with Human CNS Nicotinic and Muscarinic Receptor-Binding Properties
TLDR
D doses of Melissa officinalis at or above the maximum employed here can improve cognitive performance and mood and may therefore be a valuable adjunct in the treatment of Alzheimer's disease.
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The results confirm previous observations of the cholinesterase inhibiting properties of S. officinalis, and improved mood and cognitive performance following the administration of single doses to healthy young participants.
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The results of the study show that MO can improve learning and memory in the PAL task and further investigation is needed to enhance the understanding of the neurobiological mechanisms of the MO extract and its effects onlearning and memory.
The efficacy of lemon balm (Melissa officinalis L.) alone and combined with lemon balm—Nepeta menthoides on premenstrual syndrome and quality of life among students: A randomized controlled trial
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Negative Chronotropic and Antidysrhythmic Effects of Hydroalcoholic Extract of Lemon Balm (Melissa Officinalis L.) on CaCl2-Induced Arrhythmias in Rats
TLDR
Melissa officinalis was considered to be an antiarrhythmic agent because it reduced the percentage of incidence of VPB, VT, and VF in the groups that received it.
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Acute and Chronic Effects of Green Oat (Avena sativa) Extract on Cognitive Function and Mood during a Laboratory Stressor in Healthy Adults: A Randomised, Double-Blind, Placebo-Controlled Study in Healthy Humans
TLDR
These results confirm the acute cognitive effects of Avena sativa extracts and are the first to demonstrate that chronic supplementation can benefit cognitive function and modulate the physiological response to a stressor.
Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice.
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