Attenuation of Hepatic Graft-versus-host Disease in Allogeneic Recipients of MyD88-deficient Donor Bone Marrow

@inproceedings{Lim2015AttenuationOH,
  title={Attenuation of Hepatic Graft-versus-host Disease in Allogeneic Recipients of MyD88-deficient Donor Bone Marrow},
  author={Ji-Young Lim and Young-Kwan Lee and Sung-Eun Lee and Ji-Min Ju and Gyeong-sin Park and Eun Young Choi and Chang-Ki Min},
  booktitle={Immune network},
  year={2015}
}
Acute graft-versus-host-disease (GVHD) is characterized by selective damage to the liver, the skin, and the gastrointestinal tract. Following allogeneic hematopoietic stem cell transplantation, donor bone marrow (BM) cells repopulate the immune system of the recipient. We previously demonstrated that the acute intestinal GVHD (iGVHD) mortality rate was higher in MyD88-deficient BM recipients than that in the control BM recipients. In the present study, the role of MyD88 (expressed by donor BM… CONTINUE READING