Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells.

@article{Huang1997AttenuationOG,
  title={Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells.},
  author={C L Huang and John R Hepler and Alfred G. Gilman and Susanne M Mumby},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 12},
  pages={6159-63}
}
Protein regulators of G protein signaling (RGS proteins) were discovered as negative regulators of heterotrimeric G protein-mediated signal transduction in yeast and worms. Experiments with purified recombinant proteins in vitro have established that RGS proteins accelerate the GTPase activity of certain G protein alpha subunits (the reaction responsible for their deactivation); they can also act as effector antagonists. We demonstrate herein that either of two such RGS proteins, RGS4 or GAIP… CONTINUE READING
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