Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells.

Abstract

Protein regulators of G protein signaling (RGS proteins) were discovered as negative regulators of heterotrimeric G protein-mediated signal transduction in yeast and worms. Experiments with purified recombinant proteins in vitro have established that RGS proteins accelerate the GTPase activity of certain G protein alpha subunits (the reaction responsible… (More)

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@article{Huang1997AttenuationOG, title={Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells.}, author={Chun Huang and John R. Hepler and Alfred G. Gilman and Susanne M Mumby}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1997}, volume={94 12}, pages={6159-63} }