Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0.

@article{LeesMiller1996AttenuationOD,
  title={Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0.},
  author={Susan P Lees-Miller and Melissa C Long and M A Kilvert and Victoria Lam and Stephen A. Rice and Charlotte A. Spencer},
  journal={Journal of virology},
  year={1996},
  volume={70 11},
  pages={7471-7}
}
The DNA-dependent protein kinase (DNA-PK) is involved in several fundamental nuclear processes, including DNA double-strand break repair, V(D)J recombination, and transcription by RNA polymerases I and II. In this study, we show that infection of mammalian cells with herpes simplex virus type 1 attenuates DNA-PK activity by specifically depleting the p350/DNA-PKcs catalytic subunit. The half-life of the p350/DNA-PKcs protein decreases from greater than 24 h to less than 4 h following infection… CONTINUE READING

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