Attenuation of DNA damage-induced p53 expression by arsenic: a possible mechanism for arsenic co-carcinogenesis.

@article{Shen2008AttenuationOD,
  title={Attenuation of DNA damage-induced p53 expression by arsenic: a possible mechanism for arsenic co-carcinogenesis.},
  author={Shengwen Shen and Jane HyoJin Lee and Michael Weinfeld and X Chris Le},
  journal={Molecular carcinogenesis},
  year={2008},
  volume={47 7},
  pages={508-18}
}
Inhibition of DNA repair processes has been suggested as one predominant mechanism in arsenic co-genotoxicity. However, the underlying mode of action responsible for DNA repair inhibition by arsenic remains elusive. To further elucidate the mechanism of repair inhibition by arsenic, we examined the effect of trivalent inorganic and methylated arsenic metabolites on the repair of benzo(a)pyrene diol epoxide (BPDE)-DNA adducts in normal human primary fibroblasts and their effect on repair-related… CONTINUE READING

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