Attenuation of DNA damage in canine hearts preserved by continuous hypothermic perfusion.

@article{Fitton2005AttenuationOD,
  title={Attenuation of DNA damage in canine hearts preserved by continuous hypothermic perfusion.},
  author={Torin P Fitton and Christopher J. Barreiro and Pramod Bonde and Chiming Wei and Fred Gage and Ren{\'e} Rodriguez and John V. Conte},
  journal={The Annals of thoracic surgery},
  year={2005},
  volume={80 5},
  pages={1812-20}
}
BACKGROUND Continuous hypothermic perfusion is a novel cardiac preservation technique. Reactive oxygen species play a role in ischemia reperfusion injury and limit organ preservation. Oxidative stress mediates a DNA mismatch lesion (7, 8-dihydro-8-oxoguanine [8-oxo-G]), which is repaired by the enzymes MutY homologue (MYH), 8-oxo-G glycosylase (OGG1), and MutS homologue 2 (MSH2). We hypothesized that continuous hypothermic perfusion would allow for maintenance of cardiac function while… CONTINUE READING