Attenuation of Cytogenetic Damage by 2-Mercaptoethanesulfonate in Cultured Human Lymphocytes Exposed to Cyclophosphamide and Its Reactive Metabolites 1

@inproceedings{Wilmer2006AttenuationOC,
  title={Attenuation of Cytogenetic Damage by 2-Mercaptoethanesulfonate in Cultured Human Lymphocytes Exposed to Cyclophosphamide and Its Reactive Metabolites 1},
  author={James L. Wilmer and Gregory L. Erexson and Andrew D. Kligerman},
  year={2006}
}
Cyclophosphamide (CP) is metabolized to the reactive inter mediates, phosphoramide mustard (RAM) and acrolein (AC), which have generally different molecular binding targets. Sodium2-rnercaptoethanesulfonic acid (MESNA) has been used clinically to alleviate hemorrhagic cystitis caused by CP chemotherapy, has exhibited anticarcinogenic effects in rats exposed… CONTINUE READING