Attenuation of Cocaine's Reinforcing and Discriminative Stimulus Effects via Muscarinic M1 Acetylcholine Receptor Stimulation

@article{Thomsen2010AttenuationOC,
  title={Attenuation of Cocaine's Reinforcing and Discriminative Stimulus Effects via Muscarinic M1 Acetylcholine Receptor Stimulation},
  author={Morgane Thomsen and P. Jeffrey Conn and Craig W. Lindsley and J{\"u}rgen Wess and Joon Y. Boon and Brian Shane Fulton and Anders Fink-Jensen and S. Barak Caine},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2010},
  volume={332},
  pages={959 - 969}
}
Muscarinic cholinergic receptors modulate dopaminergic function in brain pathways thought to mediate cocaine's abuse-related effects. Here, we sought to confirm and extend in the mouse species findings that nonselective muscarinic receptor antagonists can enhance cocaine's discriminative stimulus. More importantly, we tested the hypothesis that muscarinic receptor agonists with varied receptor subtype selectivity can blunt cocaine's discriminative stimulus and reinforcing effects; we… Expand
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