Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression.

@article{Gao2015AttenuationOC,
  title={Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression.},
  author={Ming Gao and Xiaohui Wang and Xia Zhang and Tuanzhu Ha and He Ma and Li Liu and John H. Kalbfleisch and Xiang Gao and Race L. Kao and David M. L. Williams and Chuanfu Li},
  journal={Journal of immunology},
  year={2015},
  volume={195 2},
  pages={672-82}
}
Cardiac dysfunction is a major consequence of sepsis/septic shock and contributes to the high mortality of sepsis. Innate and inflammatory responses mediated by TLRs play a critical role in sepsis-induced cardiac dysfunction. MicroRNA-146 (miR-146) was first identified as a negative regulator in innate immune and inflammatory responses induced by LPS. This study examined whether miR-146a will have a protective effect on sepsis-induced cardiac dysfunction. Lentivirus-expressing miR-146a (LmiR… CONTINUE READING
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