Attenuation of CXCR4 responses by CCL18 in acute lymphocytic leukemia B cells.

@article{Catusse2010AttenuationOC,
  title={Attenuation of CXCR4 responses by CCL18 in acute lymphocytic leukemia B cells.},
  author={Julie Catusse and Stefan Wollner and Marion Leick and Percy Schroettner and Ingrid U. Schraufst{\"a}tter and Meike Burger},
  journal={Journal of cellular physiology},
  year={2010},
  volume={225 3},
  pages={792-800}
}
CCL18 and CXCL12 are homeostatic chemokines with high constitutive concentrations in serum. Elevated levels of CCL18 have been described in various diseases including childhood acute lymphocytic leukemia (ALL) but its functions remain poorly characterized. Its receptor has not been identified, but functional cellular responses like lymphocyte chemotaxis have been described. CXCL12 is a pivotal chemokine for hematopoiesis and B cell homing processes. We demonstrate that CCL18 interferes with… CONTINUE READING