Attenuation of CHOP-mediated myocardial apoptosis in pressure-overloaded dominant negative p38α mitogen-activated protein kinase mice.

@article{Sari2011AttenuationOC,
  title={Attenuation of CHOP-mediated myocardial apoptosis in pressure-overloaded dominant negative p38α mitogen-activated protein kinase mice.},
  author={Flori R. Sari and Bambang Widyantoro and Rajarajan A Thandavarayan and Meilei Harima and Arun Prasath Lakshmanan and Shaosong Zhang and Anthony J. Muslin and Kenji Suzuki and Makoto Kodama and Kenichi Watanabe},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2011},
  volume={27 5},
  pages={487-96}
}
BACKGROUND/AIMS Pressure overload stimulation is known to elicit disturbances in the endoplasmic reticulum (ER), which leads to ER stress (ERS). p38 mitogen-activated protein kinase (MAPK) plays an important role in mediating apoptotic processes, however, the roles of this kinase in activating ERS-initiated apoptosis in pressure-overloaded hearts are largely unknown. METHODS We clarified the role of p38α MAPK in ERS-associated apoptosis by subjecting transgenic mice displaying cardiac… CONTINUE READING