Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3β Pathway by Hesperidin in Wistar Rats

@article{JustinThenmozhi2018AttenuationOA,
  title={Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3$\beta$ Pathway by Hesperidin in Wistar Rats},
  author={Arokiasamy Justin-Thenmozhi and Mathiyazahan Dhivya Bharathi and R. Kiruthika and T. Manivasagam and Anupom Borah and M. Essa},
  journal={Neurotoxicity Research},
  year={2018},
  volume={34},
  pages={463-476}
}
Hesperidin, a flavanoglycone abundantly present in citrus fruits, is reported to have antioxidant, anti-inflammatory, and neuroprotective properties. Previous reports from our laboratory indicated the neuroprotective effect of hesperidin against aluminum chloride (AlCl3)-induced memory loss, acetylcholine esterase hyperactivity, oxidative stress, and enhanced expression of amyloid β protein biosynthesis-related markers. However, their role on AlCl3-induced inflammation, caspase activation, Tau… Expand
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