Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid System

  title={Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid System},
  author={Meliha Karsak and E. Gaffal and R. Date and Lihua Wang-Eckhardt and J. Rehnelt and S. Petrosino and K. Starowicz and R. Steuder and E. Schlicker and B. Cravatt and R. Mechoulam and R. Buettner and S. Werner and V. Di Marzo and T. T{\"u}ting and A. Zimmer},
  pages={1494 - 1497}
  • Meliha Karsak, E. Gaffal, +13 authors A. Zimmer
  • Published 2007
  • Medicine
  • Science
  • Allergic contact dermatitis affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes for occupational diseases. In an animal model for cutaneous contact hypersensitivity, we show that mice lacking both known cannabinoid receptors display exacerbated allergic inflammation. In contrast, fatty acid amide hydrolase–deficient mice, which have increased levels of the endocannabinoid anandamide, displayed reduced allergic responses in the skin. Cannabinoid… CONTINUE READING
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