Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid System

@article{Karsak2007AttenuationOA,
  title={Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid System},
  author={Meliha Karsak and Evelyn Gaffal and Rahul Date and Lihua Wang-Eckhardt and Jennifer Rehnelt and Stefania Petrosino and Katarzyna Starowicz and Regina Steuder and E Schlicker and Benjamin F. Cravatt and Raphael Mechoulam and Reinhard Buettner and Sabine Werner and Vincenzo Di Marzo and Thomas T{\"u}ting and Andreas Zimmer},
  journal={Science},
  year={2007},
  volume={316},
  pages={1494 - 1497}
}
Allergic contact dermatitis affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes for occupational diseases. In an animal model for cutaneous contact hypersensitivity, we show that mice lacking both known cannabinoid receptors display exacerbated allergic inflammation. In contrast, fatty acid amide hydrolase–deficient mice, which have increased levels of the endocannabinoid anandamide, displayed reduced allergic responses in the skin. Cannabinoid… 
View on AAAS
cannabisplus.net
253 Citations
Highly Influential Citations
3
Background Citations
68
Methods Citations
5
Results Citations
3

253 Citations

The Endocannabinoid System and Its Role in Eczematous Dermatoses
TLDR
The role of endocannabinoids in maintaining skin health and homeostasis is highlighted and evidence on the role of ECS in several eczematous dermatoses including atopic dermatitis, asteatotic eczema, irritant contact dermatitis; and chronic pruritus is discussed.
Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis.
TLDR
This review will integrate the recent advancement of immunological mechanisms of both the sensitization and elicitation phases of CHS into the classic view, and will discuss updated mechanisms on its development and future directions.
Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis.
Regulatory Role of Cannabinoids for Skin Barrier Functions and Cutaneous Inflammation
Topical cannabinoid receptor 1 agonist attenuates the cutaneous inflammatory responses in oxazolone‐induced atopic dermatitis model
TLDR
The effects of CBR agonists on skin inflammation, using acute and chronic inflammation animal models, are investigated.
The endocannabinoid system of the skin. A potential approach for the treatment of skin disorders
The potential role of cannabinoids in dermatology
TLDR
Cannabinoids have demonstrated anti-inflammatory, antipruritic, anti-ageing, and antimalignancy properties by various mechanisms including interacting with the newly found endocannabinoid system of the skin thereby providing a promising alternative to traditional treatments.
Anti‐inflammatory activity of topical THC in DNFB‐mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors
TLDR
The mechanism of the anti‐inflammatory activity of THC and the role of CB1 and CB2 receptors are investigated and related cannabinoids are considered for the treatment of inflammatory skin diseases.
Cannabinoid 1 Receptors in Keratinocytes Modulate Proinflammatory Chemokine Secretion and Attenuate Contact Allergic Inflammation
TLDR
Results demonstrate that CB1 receptors are functionally expressed by KCs in vivo and help to limit the secretion of proinflammatory chemokines that regulate T cell–dependent inflammation in the effector phase of CHS.
Allergic Contact Dermatitis and the Endocannabinoid System: From Mechanisms to Skin Care
TLDR
A therapeutic endocannabinoid-based strategy could be useful in numerous and diverse pathological conditions: mood and anxiety disorders, movement disorders, inflammatory and neuropathic pains, multiple sclerosis and spinal cord injury, cancer, atherosclerosis and cardiovascular diseases, stroke, glaucoma, obesity and metabolic syndrome, addictions, and osteoporosis.
...
...

References

SHOWING 1-10 OF 25 REFERENCES
Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity.
  • S. Grabbe, T. Schwarz
  • Biology, Medicine
    American journal of contact dermatitis : official journal of the American Contact Dermatitis Society
  • 1996
Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2-Arachidonoylglycerol in Oxazolone-Induced Contact Dermatitis in Mice1
TLDR
The results strongly suggest that the CB2 receptor and 2-AG play important stimulative roles in the sensitization, elicitation, and exacerbation of allergic inflammation.
Cannabinoid-based drugs as anti-inflammatory therapeutics
  • T. Klein
  • Biology, Medicine
    Nature Reviews Immunology
  • 2005
TLDR
A wealth of information indicates that marijuana-derived cannabinoids have immunosuppressive and anti-inflammatory properties, and on the basis of this mode of action, the therapeutic usefulness of these drugs in chronic inflammatory diseases is now being reassessed.
The Endocannabinoid System in Human Keratinocytes
TLDR
Unprecedented evidence is reported that spontaneously immortalized human keratinocytes partake in the peripheral endocannabinoid system and show a novel signaling mechanism of CB1 receptors, which may have important implications in epidermal differentiation and skin development.
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
TLDR
Results indicate that FAAH is a key regulator of anandamide signaling in vivo, setting an endogenous cannabinoid tone that modulates pain perception, and may represent an attractive pharmaceutical target for the treatment of pain and neuropsychiatric disorders.
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
TLDR
Most, but not all, CNS effects of Delta9-THC are mediated by the CB1 receptor, which accounts for the abuse potential of cannabis, while other effects such as analgesia suggest potential medicinal applications.
Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin.
Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor.
Interferon inhibits the suppressor T cell response of delayed-type hypersensitivity
TLDR
This work studied the effect of an electrophoretically purified mouse interferon (IFN-α and β) preparation on the Ts response to dinitrofluorobenzene (DNFB) in BALB/c mice and found that small amounts of the preparation inhibited the generation of Ts by DNBSO3 in vivo, and the function of Ts both in the recipient animals when injected i.v.
Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice
TLDR
A ligand/receptor relationship between AEA and CB1 in these two brain regions, where tonic activation of the receptor may tightly regulate the biosynthesis of its endogenous ligand is suggested.
...
...