Attenuation by genistein of sodium-chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.

@article{Tatsuta1999AttenuationBG,
  title={Attenuation by genistein of sodium-chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.},
  author={Masaharu Tatsuta and Hiroyashu Iishi and Miyako Baba and Hiroyuki Yano and Hisanori Uehara and Akihiko Nakaizumi},
  journal={International journal of cancer},
  year={1999},
  volume={80 3},
  pages={396-9}
}
The effects of prolonged administration of genistein, a tyrosine-kinase inhibitor, on sodium-chloride-enhanced induction of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine, and the labeling and apoptotic indices and vessel counts in the gastric mucosa and gastric cancers, were investigated in Wistar rats. After 25 weeks of the carcinogen treatment, rats were fed chow pellets containing 10% sodium chloride and were given s.c. injections of genistein at dosages of 15 mg/kg… CONTINUE READING

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