Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring

@inproceedings{Wu2009AttenuationBD,
  title={Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring},
  author={Ling-Yi Wu and Jain-Fang Chen and P. L. Tao and Eagle Yi-Kung Huang},
  booktitle={Journal of Biomedical Science},
  year={2009}
}
Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presented, however, for the effect of DM co-administered with morphine during pregnancy on morphine-induced reward and behavioral sensitization (possibly related to the potential to induce morphine addiction) in morphine-exposed offspring. Conditioned place preference and locomotor activity tests… CONTINUE READING

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