Attenuation and recovery of nerve growth factor receptor mRNA in dorsal root ganglion neurons following axotomy.

@article{Krekoski1996AttenuationAR,
  title={Attenuation and recovery of nerve growth factor receptor mRNA in dorsal root ganglion neurons following axotomy.},
  author={Craig A. Krekoski and Irma M. Parhad and Arthur W Clark},
  journal={Journal of neuroscience research},
  year={1996},
  volume={43 1},
  pages={1-11}
}
The actions of nerve growth factor (NGF) are mediated by two receptor proteins, trk and p75. Recent evidence indicates that NGF upregulates the expression of both trk and p75 in responsive neurons including rat dorsal root ganglion (DRG) neurons. Axotomy by disconnecting the neuron from its source of target-derived NGF is predicted to lead to the downregulation of trk and p75 expression. However, previous studies of the effects of axotomy on trk and p75 mRNA expression in rat DRG have yielded… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…