Attenuation and persistence of and ability to induce protective immunity to a Staphylococcus aureus aroA mutant in mice.

@article{Buzzola2006AttenuationAP,
  title={Attenuation and persistence of and ability to induce protective immunity to a Staphylococcus aureus aroA mutant in mice.},
  author={Fernanda Roxana Buzzola and Mar{\'i}a Sol Barbagelata and Roberto L. Caccuri and Daniel O. Sordelli},
  journal={Infection and immunity},
  year={2006},
  volume={74 6},
  pages={3498-506}
}
Staphylococcus aureus is the most important etiological agent of bovine mastitis, a disease that causes significant economic losses to the dairy industry. Several vaccines to prevent the disease have been tested, with limited success. The aim of this study was to obtain a suitable attenuated aro mutant of S. aureus by transposon mutagenesis and to demonstrate its efficacy as a live vaccine to induce protective immunity in a murine model of intramammary infection. To do this, we transformed S… CONTINUE READING
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