Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region.

@article{Durbin2001AttenuationAI,
  title={Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region.},
  author={Anna Durbin and Ruth A. Karron and W Sun and D W Vaughn and M J Reynolds and J R Perreault and B Thumar and Ruhe Men and C J Lai and William R Elkins and Robert M. Chanock and B R Murphy and Stephen S. Whitehead},
  journal={The American journal of tropical medicine and hygiene},
  year={2001},
  volume={65 5},
  pages={405-13}
}
The recombinant dengue virus type-4 vaccine candidate 2AA30 was attenuated in rhesus monkeys due to an engineered 30-nucleotide deletion in the 3'-untranslated region of the viral genome. A clinical trial to evaluate the safety and immunogenicity of a single dose of 2Adelta30 was conducted with 20 adult human volunteers. The vaccine candidate was well tolerated and did not cause systemic illness in any of the 20 volunteers. Viremia was detectable in 14 volunteers at a mean level of 1.6 log10… CONTINUE READING
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