Attenuated virulence of uridine-uracil auxotrophs of Aspergillus fumigatus.

  title={Attenuated virulence of uridine-uracil auxotrophs of Aspergillus fumigatus.},
  author={Christophe d'Enfert and M Diaquin and A Delit and Nicole Wuscher and J. P. Debeaupuis and Michel Ren{\'e} Huerre and Jean Paul Latg{\'e}},
  journal={Infection and immunity},
  volume={64 10},
Aspergillus fumigatus mutants that are deficient in the de novo UMP biosynthesis pathway because of a mutation in the pyrG gene encoding orotidine-5'-phosphate decarboxylase (and therefore auxotrophic for uridine or uracil) were evaluated in a murine model of invasive aspergillosis. These mutants were entirely nonpathogenic, and mutant conidia remained ungerminated in alveolar macrophages. Both the germination and virulence defects could be restored by supplementing the drinking water of the… CONTINUE READING
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