Attenuated sympathetic nerve responses after 24 hours of bed rest.

@article{Khan2002AttenuatedSN,
  title={Attenuated sympathetic nerve responses after 24 hours of bed rest.},
  author={M Saddam Hossain Khan and Allen R Kunselman and Urs A. Leuenberger and William R. Davidson and Chester A. Ray and Kristen S. Gray and Cynthia S Hogeman and Lawrence I. Sinoway},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={282 6},
  pages={H2210-5}
}
Bed rest reduces orthostatic tolerance. Despite decades of study, the cause of this phenomenon remains unclear. In this report we examined hemodynamic and sympathetic nerve responses to graded lower body negative pressure (LBNP) before and after 24 h of bed rest. LBNP allows for baroreceptor disengagement in a graded fashion. We measured heart rate (HR), cardiac output (HR x stroke volume obtained by echo Doppler), and muscle sympathetic nerve activity (MSNA) during a progressive and graded… CONTINUE READING

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