Attenuated pulse size, disorderly growth hormone and prolactin secretion with preserved nyctohemeral rhythm distinguish irradiated from surgically treated acromegaly patients.

@article{Klaauw2007AttenuatedPS,
  title={Attenuated pulse size, disorderly growth hormone and prolactin secretion with preserved nyctohemeral rhythm distinguish irradiated from surgically treated acromegaly patients.},
  author={Agatha A van der Klaauw and Alberto M Pereira and Sjoerd W van Thiel and Marijke Frolich and A. Iranmanesh and Johannes D. Veldhuis and Ferdinand Roelfsema and Johannes Anthonius Romijn},
  journal={Clinical endocrinology},
  year={2007},
  volume={66 4},
  pages={489-98}
}
BACKGROUND Radiation induces time-dependent loss of anterior pituitary function, attributed to damage of the pituitary gland and hypothalamic centres. The development of growth hormone deficiency (GHD) in irradiated acromegaly patients is not well defined. OBJECTIVE Detailed analysis of spontaneous 24-h GH and prolactin (PRL) secretion in relation to other pituitary functions and serum IGF-I concentrations in an attempt to find criteria for GHD in acromegalic patients with a GH response < 3… CONTINUE READING

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