Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats.

@article{RuizOpazo2004AttenuatedHL,
  title={Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats.},
  author={Nelson Ruiz-Opazo and Kenneth S. Kosik and Lyle V. Lopez and Pia D. Bagamasbad and Lorenz R. B. Ponce and Victoria L. M. Herrera},
  journal={Molecular medicine},
  year={2004},
  volume={10 1-6},
  pages={
          36-44
        }
}
Alzheimer's disease (AD) is characterized by increased beta amyloid (Abeta) levels, extracellular Abeta deposits in senile plaques, neurofibrillary tangles, and neuronal loss. However, the physiological role of normal levels of Abeta and its parent protein, the amyloid precursor protein (APP) are unknown. Here we report that low-level transgenic (Tg) expression of the Swedish APP mutant gene (APPswe) in Fischer-344 rats results in attenuated age-dependent cognitive performance decline in 2… CONTINUE READING
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The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer’s disease

  • MA Westerman
  • J. Neurosci
  • 2002
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