Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.

@article{Yang2005AttenuatedHI,
  title={Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.},
  author={Liu Yang and Ram{\'o}n Bataller and Jennyfer Dulyx and Thomas M. Coffman and Pere Gin{\`e}s and Richard A. Rippe and David Brenner},
  journal={Journal of hepatology},
  year={2005},
  volume={43 2},
  pages={317-23}
}
BACKGROUND/AIMS Pharmacological blockade of the renin-angiotensin system (RAS) attenuates liver fibrogenesis in rats. Here, we provide genetic evidence implicating angiotensin type 1 (AT1) receptors in liver fibrogenesis. METHODS Wild type (WT) and AT1a knockout [AT1a (-/-)] mice were subjected to either sham operation or bile-duct ligation. Fibrosis was assessed by Sirius Red staining and hydroxyproline hepatic content. Fibrogenic and inflammatory cytokines were measured by ELISA. RESULTS… CONTINUE READING