Attenuated expression of the mga virulence regulon in an M serotype 50 mouse-virulent group A streptococcal strain.

@article{Yung1999AttenuatedEO,
  title={Attenuated expression of the mga virulence regulon in an M serotype 50 mouse-virulent group A streptococcal strain.},
  author={Daniel L Yung and Kevin S McIver and June R. Scott and Susan K. Hollingshead},
  journal={Infection and immunity},
  year={1999},
  volume={67 12},
  pages={6691-4}
}
The attenuated expression of virulence genes found in a group A streptococcal strain that is naturally pathogenic for mice was postulated to result from a defect in the strain's multigene regulator, Mga. The sequence of the mga gene reveals three amino acid changes in the gene product that might affect protein function. The defect in the mga gene was complemented by providing either the closely similar mga4 allele or a more divergent mga1 allele in trans. Complementation increased the amount of… CONTINUE READING