Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice.

@article{Es2009AttenuatedAU,
  title={Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice.},
  author={Thomas van Es and Gijs H M van Puijvelde and Orn{\'e}lia H Ramos and Filip M E Segers and Leo A. B. Joosten and Wim B. van den Berg and I M Michon and Paula de Vos and Th J C van Berkel and J. J. W. Kuiper},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={388 2},
  pages={261-5}
}
Atherosclerosis is an inflammatory disease characterized by the influx of macrophages and T cells and IL-17 may connect innate and adaptive immune responses involved in atherogenesis. We investigated the role of IL-17 receptor signaling in atherosclerosis and transplanted LDLr deficient recipient mice with IL-17R deficient bone marrow. Induction of atherosclerosis by Western-type diet induced a 46% reduction in lesion size in the aortic root and the plaque composition revealed no significant… CONTINUE READING

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