Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression.

Abstract

Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder of unknown origin. We previously demonstrated that monocytes from CRMO patients fail to express the immune-modulatory cytokine interleukin-10 (IL-10) in a chromatin dependent manner. Here, we demonstrate that attenuated extracellular-signal regulated kinase (ERK)1 and 2… (More)
DOI: 10.1016/j.clim.2012.07.012

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