Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution.

@article{Pervushin1997AttenuatedTR,
  title={Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution.},
  author={Konstantin Pervushin and Roland Riek and Gerhard Wider and Kurt W{\"u}thrich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 23},
  pages={
          12366-71
        }
}
  • Konstantin Pervushin, Roland Riek, +1 author Kurt Wüthrich
  • Published in
    Proceedings of the National…
    1997
  • Chemistry, Medicine
  • Fast transverse relaxation of 1H, 15N, and 13C by dipole-dipole coupling (DD) and chemical shift anisotropy (CSA) modulated by rotational molecular motions has a dominant impact on the size limit for biomacromolecular structures that can be studied by NMR spectroscopy in solution. Transverse relaxation-optimized spectroscopy (TROSY) is an approach for suppression of transverse relaxation in multidimensional NMR experiments, which is based on constructive use of interference between DD coupling… CONTINUE READING

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    References

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    SHOWING 1-4 OF 4 REFERENCES

    Pervushin et al

    • N. Tjandra, Bax, A. J. Am. Chem. Soc. 119, 8076–8082. Biophysics
    • Proc. Natl. Acad. Sci. USA 94
    • 1997
    VIEW 1 EXCERPT

    NMR in Structural Biology (World Scientific, Singapore)

    • K. Wüthrich
    • 1995
    VIEW 1 EXCERPT

    The principles of nuclear magnetism

    VIEW 1 EXCERPT