Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice

@article{Vendrov2017AttenuatedSD,
  title={Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice},
  author={Aleksandr E. Vendrov and Mark D Stevenson and Samthosh V Alahari and H. Pan and S. Wickline and N. Madamanchi and M. Runge},
  journal={Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease},
  year={2017},
  volume={6}
}
  • Aleksandr E. Vendrov, Mark D Stevenson, +4 authors M. Runge
  • Published 2017
  • Medicine
  • Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
  • Background Atherosclerosis progression during aging culminates in the development of vulnerable plaques, which may increase the risk of cardiovascular events. Increased generation and/or decreased scavenging of reactive oxygen species in the vascular wall are major contributors to atherogenesis. We previously showed that superoxide dismutase 2 deficiency increased vascular oxidative stress and reduced aortic compliance in aged wild‐type mice and that young Apoe −/−/Sod2 +/− had increased… CONTINUE READING
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