Attenuated Salmonella typhimurium containing interleukin-2 decreases MC-38 hepatic metastases: a novel anti-tumor agent.

@article{Saltzman1996AttenuatedST,
  title={Attenuated Salmonella typhimurium containing interleukin-2 decreases MC-38 hepatic metastases: a novel anti-tumor agent.},
  author={Daniel A. Saltzman and Chuck P Heise and Diane E. Hasz and M Zebede and Sandra M. Kelly and Roy Curtiss and Arnold S. Leonard and Peter A.M. Anderson},
  journal={Cancer biotherapy & radiopharmaceuticals},
  year={1996},
  volume={11 2},
  pages={145-53}
}
Currently, there is no long-term effective treatment for unresectable hepatic malignancies. Salmonella sp. are known to naturally track to the liver during active infection. To develop a biological vector for delivery of Interleukin-2 (IL-2) to the liver for anti-tumor purposes, the avirulent and highly immunogenic chi 4550 strain of Salmonella typhimurium was used as a vector for IL-2. The gene for human IL-2 was cloned into plasmid pYA292 (renamed pIL-2) and inserted into the attenuated… CONTINUE READING
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