Attenuated Effect of Growth Hormone(gh) in Acidosis- and Methylprednisone(mp)-induced Growth Retardation(gr) in Weanling Rats

Acidosis and glucocorticoid excess retard linear growth. GH reverses MP-induced GR and stimulates urinary net acid excretion in mid-sized uremic rats. However, the efficacy of GH in reversing acidosis- and MP-induced GR in early postnatal life is unknown. We gave GH (0.5mg.s.c. 5d/wk × 2wk) to NH4Cl-treated(0.28M), MP-treated (6mg/kg/day), and control(H2O… (More)