Attenuated Cold Sensitivity in TRPM8 Null Mice

@article{Colburn2007AttenuatedCS,
  title={Attenuated Cold Sensitivity in TRPM8 Null Mice},
  author={Raymond W. Colburn and Mary Lou Lubin and Dennis J. Stone and Yan Wang and Danielle Lawrence and Michael R. D'Andrea and Michael R. Brandt and Yi Liu and Christopher M. Flores and Ning Qin},
  journal={Neuron},
  year={2007},
  volume={54},
  pages={379-386}
}
Thermosensation is an essential sensory function that is subserved by a variety of transducer molecules, including those from the Transient Receptor Potential (TRP) ion channel superfamily. One of its members, TRPM8 (CMR1), a ligand-gated, nonselective cation channel, is activated by both cold and chemical stimuli in vitro. However, its roles in cold thermosensation and pain in vivo have not been fully elucidated. Here, we show that sensory neurons derived from TRPM8 null mice lack detectable… 
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TRPA1 is apparently not essential for hair-cell transduction but contributes to the transduction of mechanical, cold, and chemical stimuli in nociceptor sensory neurons.
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TLDR
These findings, together with the previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system.
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TLDR
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TLDR
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TLDR
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TLDR
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