Attentional effects of nicotinic agonists in rats.

  title={Attentional effects of nicotinic agonists in rats.},
  author={Britta Hahn and Christopher G V Sharples and Susan Wonnacott and Mohammed Shoaib and Ian P. Stolerman},
  volume={44 8},
Nicotine can increase stimulus detection, response rate and speed in the five-choice serial reaction time task, a rodent test of attention. In the present experiments, four other nicotinic agonists with different pharmacological profiles were compared in the same procedure. The response profile of epibatidine resembled that previously obtained with nicotine in that response accuracy was enhanced and omission errors and correct response latency decreased. ABT-418 transiently increased accuracy… CONTINUE READING