Attentional Control of Gait and Falls: Is Cholinergic Dysfunction a Common Substrate in the Elderly and Parkinson’s Disease?

@article{Pelosin2016AttentionalCO,
  title={Attentional Control of Gait and Falls: Is Cholinergic Dysfunction a Common Substrate in the Elderly and Parkinson’s Disease?},
  author={Elisa Pelosin and Carla Ogliastro and Giovanna Lagravinese and Gaia Bonassi and Anat Mirelman and Jeffrey M. Hausdorff and Giovanni Abbruzzese and Laura Avanzino},
  journal={Frontiers in aging neuroscience},
  year={2016},
  volume={8},
  pages={104}
}
The aim of this study was to address whether deficits in the central cholinergic activity may contribute to the increased difficulty to allocate attention during gait in the elderly with heightened risk of falls. We recruited 50 participants with a history of two or more falls (33 patients with Parkinson's Disease and 17 older adults) and 14 non-fallers age-matched adults. Cholinergic activity was estimated by means of short latency afferent inhibition (SAI), a transcranial magnetic stimulation… CONTINUE READING
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