Attention-deficit and hyperactive neurobehavioural characteristics induced by perinatal hypothyroidism in rats.

@article{Negishi2005AttentiondeficitAH,
  title={Attention-deficit and hyperactive neurobehavioural characteristics induced by perinatal hypothyroidism in rats.},
  author={Takayuki Negishi and Katsuyoshi Kawasaki and Satoshi Sekiguchi and Yoshiyuki Ishii and Shigeru Kyuwa and Yoichiro Kuroda and Yasuhiro Yoshikawa},
  journal={Behavioural brain research},
  year={2005},
  volume={159 2},
  pages={323-31}
}
Thyroid hormone is essential for the proper development of the mammalian central nervous system (CNS). In the present study, we examined behavioural alterations caused by transient perinatal hypothyroidism induced by an anti-thyroid drug, propylthiouracil (PTU). This drug produces perinatal disruption of the thyroid system and subsequent behavioural changes, which we investigated using a series of behavioural tests and focusing particularly on attention-deficit/hyperactivity disorder (ADHD… CONTINUE READING