Attention-aware contrastive learning for predicting T cell receptor-antigen binding specificity

  title={Attention-aware contrastive learning for predicting T cell receptor-antigen binding specificity},
  author={Yiming Fang and Xuejun Liu and Hui Liu},
It has been verified that only a small fraction of the neoantigens presented by MHC class I molecules on the cell surface can elicit T cells. The limitation can be attributed to the binding specificity of T cell receptor (TCR) to peptide-MHC complex (pMHC). Computational prediction of T cell binding to neoantigens is an challenging and unresolved task. In this paper, we propose an attentive-mask contrastive learning model, ATMTCR, for inferring TCR-antigen binding specificity. For each input… 



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