Attention-Deficit Hyperactivity Disorder (ADHD) Comorbidity: A Case for ``Pure'' Tourette Syndrome?

@article{Denckla2006AttentionDeficitHD,
  title={Attention-Deficit Hyperactivity Disorder (ADHD) Comorbidity: A Case for ``Pure'' Tourette Syndrome?},
  author={Martha B. Denckla},
  journal={Journal of Child Neurology},
  year={2006},
  volume={21},
  pages={701 - 703}
}
  • M. Denckla
  • Published 1 August 2006
  • Psychology, Medicine
  • Journal of Child Neurology
More than a decade of research regarding the motoric characteristics of the attention-deficit hyperactivity disorder (ADHD) that accompanies Tourette syndrome has revealed unique anatomic and neurobehavioral differences and highlighted the importance of distinguishing children with this form from the 40% of children with Tourette syndrome who do not have ADHD. This distinction is important in providing guidance to parents and to patients and in formulating expectations for short- and long-term… 
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References

SHOWING 1-10 OF 16 REFERENCES
Neuropsychological status of children with Tourette's syndrome with and without attention deficit hyperactivity disorder
TLDR
To determine the frequency of learning disabilities (LD) and describe the neuropsychological profile of children with Tourette's syndrome (TS) with and without attention deficit hyperactivity disorder (ADHD), data is analyzed from 65 children selected from a larger study of LD.
Executive function in children with Tourette Syndrome and/or Attention Deficit Hyperactivity Disorder
TLDR
It is suggested that deficiencies in choice reaction time and consistency of timed responses are common to all three groups, but children with TS-only have relatively less EF impairment thanChildren with TS+ADHD or ADHD-only.
Corpus callosum morphology in children with Tourette syndrome and attention deficit hyperactivity disorder
TLDR
The findings suggest that the area of the CC is larger in children with TS, and that this difference is independent of age, handedness, intracranial area, and the diagnosis of ADHD.
Neuromotor Functioning in Children With Tourette Syndrome With and Without Attention Deficit Hyperactivity Disorder
TLDR
Findings suggest that Tourette syndrome is not associated with motor slowing and that the group with ADHD had a larger discrepancy for complexity than the other two groups.
Basal Ganglia Volumes in Children With Attention-Deficit Hyperactivity Disorder
TLDR
It is concluded that small globus pallidus volume, particularly on the left side, is associated with ADHD.
Volumetric MRI changes in basal ganglia of children with Tourette's syndrome
TLDR
This study lends further support to proposals that claim the basal ganglia is involved in the pathogenesis of TS and also suggests that the comorbid problem of ADHD is related to regional changes that differ from those primarily associated with tics.
Evidence for Unexpected Weaknesses in Learning in Children with Attention-Deficit/Hyperactivity Disorder Without Reading Disabilities
TLDR
The findings indicate that children with ADHD initially learned the same number of words as controls but showed weaknesses recalling the words after delays, suggesting that children are less efficient learners.
Disproportionate increases of white matter in right frontal lobe in Tourette syndrome
TLDR
Findings support the hypothesis proposing frontostriatal pathway involvement in the pathophysiology of the disorder and suggest the white matter connections as one explanation for basal ganglia anomalies in TS.
Oculomotor abnormalities in boys with tourette syndrome with and without ADHD.
TLDR
Oculomotor findings suggest that TS is associated with delay in initiation of motor response as evidenced by excessive latency on prosaccades, which appears to be associated with the presence of ADHD.
Executive function in fluency and recall measures among children with Tourette syndrome or ADHD
TLDR
Results provide some support for the use and analysis of process variables—particularly those related to inhibition and intrusion errors, in addition to the total score variables when assessing executive function deficits in children with ADHD and TS.
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