Attempts to stabilize a monoclonal antibody with water soluble synthetic polymers of varying hydrophobicity.

@article{Antonsen1994AttemptsTS,
  title={Attempts to stabilize a monoclonal antibody with water soluble synthetic polymers of varying hydrophobicity.},
  author={Kris P. Antonsen and Wayne R. Gombotz and Allan S. Hoffman},
  journal={Journal of biomaterials science. Polymer edition},
  year={1994},
  volume={6 1},
  pages={55-65}
}
Proteins are subject to a variety of physical and chemical reactions that lead to a loss of activity. These reactions are a particular problem in controlled-release devices, where temperatures and protein concentrations are high. Current approaches to increasing protein stability include the addition of saccharides, amino acids, or polymers. New synthetic… CONTINUE READING