Attempts to optimize induction and consolidation treatment in acute myeloid leukemia: results of the MRC AML12 trial.

@article{Burnett2010AttemptsTO,
  title={Attempts to optimize induction and consolidation treatment in acute myeloid leukemia: results of the MRC AML12 trial.},
  author={Alan K. Burnett and Robert K. Hills and Donald W. Milligan and Anthony H. Goldstone and Archibald Grant Prentice and Mary-Frances McMullin and Andrew Duncombe and Brenda E. S. Gibson and Keith Wheatley},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2010},
  volume={28 4},
  pages={586-95}
}
PURPOSE To optimize treatment for younger patients with acute myeloid leukemia and high-risk myelodysplastic syndrome by comparing induction options and the number of consolidation courses and whether consolidation should include transplantation. PATIENTS AND METHODS We randomly assigned 1,658 patients younger than age 60 years to receive mitoxantrone/cytarabine/etoposide versus cytarabine/daunorubicin/etoposide and subsequently 1,193 patients to daunorubicin/cytarabine/thioguanine (DAT… CONTINUE READING

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