Attempts to detect virus-specific DNA sequences in human tumors

@article{Wolf1975AttemptsTD,
  title={Attempts to detect virus-specific DNA sequences in human tumors},
  author={Hoepfner Wolf and Harald Hausen and George Klein and Volker Becker and Gertrude Henle and Werner Henle},
  journal={Medical Microbiology and Immunology},
  year={1975},
  volume={161},
  pages={15-21}
}
Fourteen tumors of the nasopharyngeal region were analyzed for the presence of Epstein-Barr virus-specific DNA by DNA-cRNA hybridization. These data were compared to the histology of the respective tumors and the seroreactivity of the tumor-bearing patient against EBV-related antigens. With one exception, all tumor pieces containing nasopharyngeal carcinoma cells hybridized significantly with EBV-cRNA. Tumors of predominantly epithelial morphology annealed in the highest range.In situ… CONTINUE READING
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