Attacking pain at its source: new perspectives on opioids

  title={Attacking pain at its source: new perspectives on opioids},
  author={Christoph Stein and Michael Schaefer and Halina Machelska},
  journal={Nature Medicine},
The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including opioid analgesics acting outside the central nervous system, targeting of opioid peptide–containing immune cells to peripheral damaged tissue, and gene transfer to enhance opioid production at sites of injury. 

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 198 extracted citations


Publications referenced by this paper.
Showing 1-10 of 101 references

, no gain : clinical excellence and scientific rigour — lessons learned from IA morphine

  • J. Kraus
  • 2002

Similar Papers

Loading similar papers…