Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.

@article{Grotendorst1981AttachmentOS,
  title={Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.},
  author={Gary R. Grotendorst and Heikki Sepp{\"a} and Hynda K. Kleinman and Gail R. Martin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 6},
  pages={3669-72}
}
Smooth muscle cells use fibronectin to bind to type I and type III collagens but bind to type V collagen by a trypsin-resistant intrinsic glycoconjugate. The binding site on type V collagen is located in the alpha A chain. By using collagen-coated filters in a modified Boyden chamber assay for chemotaxis, it was observed that the platelet-derived growth factor was chemotactic for smooth muscle cells but that several other growth factors were inactive. We suggest that the migration of smooth… CONTINUE READING

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