Attachment of neutralizing antibodies stabilizes the capsid of poliovirus against uncoating.

@article{Wetz1993AttachmentON,
  title={Attachment of neutralizing antibodies stabilizes the capsid of poliovirus against uncoating.},
  author={K. Wetz},
  journal={Virology},
  year={1993},
  volume={192 2},
  pages={465-72}
}
Poliovirus capsid is rapidly and irreversibly degraded upon treatment in hypotonic buffer at 37 degrees C. However, the attachment of neutralizing antibodies stabilized the virus capsid against degradation by similar treatment. This was demonstrated by the use of antisera to poliovirus from rabbits and other mammalian species. As shown with neutralizing antibodies, the degree of capsid stabilization paralleled the number of bound IgG molecules per virion and the rate of neutralization. Upon… CONTINUE READING