Attachment of capsular polysaccharide to the cell wall in Streptococcus pneumoniae.

@article{Eberhardt2012AttachmentOC,
  title={Attachment of capsular polysaccharide to the cell wall in Streptococcus pneumoniae.},
  author={Alice Eberhardt and Christopher N. Hoyland and Daniela Vollmer and Stephanie Bisle and Robert M. Cleverley and Ola Johnsborg and Leiv Sigve H{\aa}varstein and Richard J. Lewis and Waldemar Vollmer},
  journal={Microbial drug resistance},
  year={2012},
  volume={18 3},
  pages={240-55}
}
Streptococcus pneumoniae protects itself from components of the human immune defense system by a thick polysaccharide capsule, which in most serotypes is covalently attached to the cell wall peptidoglycan. Members of the LytR-Cps2A-Psr (LCP) protein family have recently been implicated in the attachment of anionic polymers to peptidoglycan in Gram-positive bacteria, based on genetic evidence from Bacillus subtilis mutant strains and on the crystal structure of S. pneumoniae Cps2A containing a… CONTINUE READING