Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes.

@article{Kranz1984AttachmentOA,
  title={Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes.},
  author={David M. Kranz and Susumu Tonegawa and Herman N. Eisen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 24},
  pages={7922-6}
}
The molecular basis for the dependence of antigen recognition by T cells on products of the major histocompatibility complex (MHC) is unknown, and the antigenic structures that are actually bound by T-cell receptors are ill-defined. In this study, we asked whether a monoclonal antibody (mAb) that reacts with the T-cell receptor of a clone of murine cytotoxic T lymphocytes (CTL) and not with the receptors of other CTL clones can substitute for that clone's natural ligand in specific cytolytic… CONTINUE READING
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