Attachment and fusion inhibitors potently prevent dendritic cell-driven HIV infection.


Dendritic cells (DCs) efficiently transfer captured (trans) or de novo-produced (cis) virus to CD4 T cells. Using monocyte-derived DCs, we evaluated entry inhibitors targeting HIV envelope (BMS-C, T-1249) or CCR5 (CMPD167) for their potency to prevent DC infection, DC-driven infection in T cells in trans and cis, and direct infection of DC-T-cell mixtures… (More)
DOI: 10.1097/QAI.0b013e3181ff2aa5